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The name 25I-NBOMe, which short-hand for 2C-I-NBOMe, is a derivative of the phenethylamine psychedelic 2C-I.
It had no history of human use before being sold online as a designer drug in 2010..
It differs from 2C-I structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. 25I-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family. This NBOMe addition contains a methoxy ether CH3O- bound to a benzene ring at R2
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25I-NBOMe has efficacy at the 5-HT2A receptor where it acts as an unusually potent and selective partial agonist.However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
The Ki values of the following targets were greater than 500 Ki: 5-HT1A, D3, H2, 5-HT1D, α1A adrenergic, δ opioid, serotonin reuptake transporter, 5-HT5A, 5-HT1B, D2, 5-HT7, D1, 5-HT3, 5-HT1E, D5, muscarinic M1-M5, H3, and the dopamine reuptake transporter
In terms of intentional consumption of high doses, there is a long history in some sub-cultures of “thumbprinting,” where an individual dips their thumb into, 25i nbome blotter, pure LSD powder and licks it clean. Although it’s difficult to estimate the number of users who have done this or the dose they may have consumed, it is a common enough behavior that it has it’s own name
Since the first intentional ingestion in 1943, tens of millions of users in the United States have tried LSD. The total number of global users is unknown, but is certainly at least hundreds of millions.